![]() Riippi M, Antikainen O, Niskanen T, Yliruusi J. Crushing strength, disintegration time and weight variation of tablets compressed from three Avicel PH grades and their mixtures. Modern pharmaceutics third edition, revised and expanded. Functionality comparison of 3 classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution. Design and evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulphate. The influence of excipients on drug release from hydroxypropyl methylcellulose matrices. Investigation of swelling/degradation behaviour of alginate beads crosslinked with Ca 2+ and Ba 2+ ions. Stability of ion exchange resin under freeze-thaw or dry-wet environment. Rockville: The United States Pharmacopeial Convention 2006. The United States Pharmacopeial Convention. Release and diffusional modeling of metronidrazole lipid matrices. London: The Royal Pharmaceutical Society of Great Britain 1996. Handbook of clinical pharmacokinetic data. ![]() Effect of a pharmaceutical cationic exchange resin on the properties of controlled release diphenhydramine hydrochloride matrices using Methocel K4M or Ethocel 7cP as matrix formers. 1998 46:321–7.Īkkaramongkolporn P, Ngawhirunpat T, Nunthanid J, Opanasopit P. Effect of ion exchange resins on the drug release from matrix tablets. The effect of pore formers on the controlled release of cefadroxil from a polyurethane matrix. Swelling and erosion properties of hydroxypropyl methylcellulose (hypromellose) matrices-influence of agitation rate and dissolution medium composition. In vitro and in vivo erosion of two different hydrophilic gel matrix tablets. 2004 269:509–22.Ībrahamsson B, Alpsten M, Bake B, Larsson A, Sjogren J. Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion. 1996 140:85–95.Ĭrowley MM, Schroeder B, Fredersdorf A, Obara S, Talarico M, Kucera S, et al. Effects of polymer particle size, compaction pressure and hydrophilic polymers on drug release from matrices containing ethylcellulose. Development of sustained release matrix tablets of didanosine containing methacrylic and ethylcellulose polymers. Sanchez-Lafuente C, Faucci MT, Fernandez-Arevalo M, Alvarez-Fuentes J, Rabasco AM, Mura P. Pharmaceutical dosage forms: tablets, vol. In: Lieberman HA, Lachman L, Schwartz JB, editors. Encyclopedia of pharmaceutical technology, vol. Ion exchange resins and sustained release. The results of this study provided useful information on the utilization of ion exchange resins as release modifiers in matrix systems. EC-based matrices containing either resin displayed a propensity for disintegration caused by swelling and wicking (water adsorption) actions by the resin. However, Am64 could retard drug release under simulated gastrointestinal conditions. Dow88 strongly dissociated and lowered the drug release to a greater extent than Am64, which was weakly dissociated. In deionized water, both resins lowered drug release from HPMC-based matrices by virtue of the gelation property of matrix former and the drug exchange property of embedded resin, in other words in situ resinate formation. In contrast, the addition of Am64 increased matrix hardness and maintained the original thickness, diameter, and friability. The addition of Dow88 to the matrices decreased matrix hardness and increased thickness, diameter, and friability. The matrices were prepared by direct compression of Methocel K4M (HPMC) or Ethocel 7FP (EC) polymeric matrix formers and contained diphenhydramine hydrochloride as a model drug. This study focused on investigating and comparing between the effect of the strongly cationic exchange resin, Dowex 88 (Dow88), and the weakly cationic exchange resin, Amberlite IRP64 (Am64), on the physical properties of matrices and their drug release profiles.
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